We are a dynamic research group at the Centre for Applied Synthetic Biology and the Centre for Structural and Functional Genomics. We investigate how phenotypes and disease states emerge from the interplay of genetic determinants in yeast and human cells.
Using a combination of systematic genetic screening (trigenic interaction screens, high-content screens, overexpression screens and CRISPR screens), genome sequencing (bulk and single cell DNA and RNA sequencing), genome engineering and synthetic biology approaches, we aim to enhance our understanding of the genotype-to-phenotype relationship and genome evolution. We pursue several research themes focusing on mapping complex genetic interaction networks, from genetic network rewiring between distantly related yeast species, conditional functional redundancy and divergence of duplicated genes and complex genetic interaction network of large copy number variants in cancer (see Research).
We are located at the Centre for Applied Synthetic Biology and the Centre for Structural and Functional Genomics, Concordia University. We exchange ideas and work with our colleagues in the Department of Biology, Concordia University and use the state-of-the-art facilities of the Genome Foundry, member of the Global Biofoundries Alliance. We are also affiliated with the Rosalind & Morris Goodman Cancer Institute, McGill University and Department of Human Genetics, McGill University.
We are grateful for funding from the Cancer Research Society (CRS), Canada Research Chair Program (CIHR) (CRC), Canada Foundation for Innovation (CFI), Natural Sciences and Engineering Research Council of Canada (NSERC), Canadian Institutes of Health Research (CIHR).
Congratulations to Brittany on winning one of the Best Poster Prizes at the 5th Annual Synthetic Biology Symposium - SynBio5.0!June 12, 2023
Our manuscript on 'Evolution of chromosome arm aberrations in breast cancer through genetic network rewiring' is out on bioRxiv!May 30, 2023
Congratulations to Lynn and Rohan on receiving the SGS conference awards to attend AACR Annual Meeting 2023!Apr 27, 2023
Congratulations to Vanessa for being awarded the FRQNT MSc scholarship!Apr 20, 2023
Congratulations to Alysh for being awarded the FAS Don & Bonnie Poole Undergraduate Summer Research Internship in Science to do her undergraduate summer research project in our lab!Feb 28, 2023
Congratulations to Paria for being awarded the McGill Biomedical Research Accelerator undergraduate summer research scholarship!Jan 9, 2023
Congratulations to Vanessa for being awarded the SynBioApps scholarship!Nov 21, 2022
Congratulations to Mikey for completing his MSc!Nov 17, 2022
Congratulations to Mikey for being awarded the Best Short Talk prize at the GCI Research Day 2022!