Welcome to the Kuzmin Lab

We are a dynamic research group at the Centre for Applied Synthetic Biology and the Centre for Structural and Functional Genomics. We investigate how phenotypes and disease states emerge from the interplay of genetic determinants in yeast and human cells.

Using a combination of systematic genetic screening (trigenic interaction screens, high-content screens, overexpression screens and CRISPR screens), genome sequencing (bulk and single cell DNA and RNA sequencing), genome engineering and synthetic biology approaches, we aim to enhance our understanding of the genotype-to-phenotype relationship and genome evolution. We pursue several research themes focusing on mapping complex genetic interaction networks, from genetic network rewiring between distantly related yeast species, conditional functional redundancy and divergence of duplicated genes and complex genetic interaction network of large copy number variants in cancer (see Research).

We are located at the Centre for Applied Synthetic Biology and the Centre for Structural and Functional Genomics, Concordia University. We exchange ideas and work with our colleagues in the Department of Biology, Concordia University and use the state-of-the-art facilities of the Genome Foundry, member of the Global Biofoundries Alliance. We are also affiliated with the Rosalind & Morris Goodman Cancer Institute, McGill University and Department of Human Genetics, McGill University.

We are grateful for funding from the Cancer Research Society (CRS), Canada Research Chair Program (CIHR) (CRC), Canada Foundation for Innovation (CFI), Natural Sciences and Engineering Research Council of Canada (NSERC), Canadian Institutes of Health Research (CIHR).


May 2, 2024

Our perspective comparing karyotype evolution in species to cancer genomes is out in Chaos!

May 1, 2024

Congratulations to Mehar for being awarded CUSRA to conduct her summer project in our lab!

Mar 21, 2024

Our manuscript on the evolution of large chromosomal aberrations in breast cancer is out in Cell Reports!

Mar 10, 2024

Congratulations to Vanessa for getting a platform talk at TAGC!

Jan 11, 2024

Our preview on the trans-regulatory network in gene expression variation is out in Cell Genomics!

Jan 8, 2024

Congratulations to Lynn for successfully fast-tracking to the PhD program!

Dec 12, 2023

Congratulations to Brittany for passing her comprehensive exam!

Nov 23, 2023

Our manuscript on protein redistribution of paralogs is out on bioRxiv!

July 24, 2023

Congratulations to Vanessa for being awarded the NSERC CGS M scholarship!

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